Do you know the effects of Cordyceps sinensis?

Cordyceps sinensis (scientific name: Tibetan: དབྱར་རྩྭ་དགུན་འབུ་, also known as Cordyceps, Chinese Cordyceps, is a fungus that parasitizes insects, usually in the family Lepidoptera. Some insect larvae grow in the body [4]. Distributed in Qinghai, Tibet, Sichuan, Yunnan, Gansu, and parts of Nepal, India, and Bhutan near the southern foot of the Himalayas in China [5]. Found in alpine meadows and alpine shrubs The epithet "sinensis" means "Chinese", and it is a Chinese geographical indication product.

Cordyceps sinensis grows on grassy slopes near the snow line in alpine meadow shrub belts at an altitude of 3,000 to 5,000 meters. A fungus spore in the soil parasitizes the larvae, grows in the larvae, absorbs its nutrients until it dies [8]. In winter, after the larvae of the bat moth are parasitized by the Cordyceps fungus and die, the internal tissue and shell will combine with the mycelium to form a hard mycelium, because the appearance is still like a larva, and it is called "winter worm" at this time. One winter, when the next spring comes, the mycelium of the fungus begins to grow. In summer, it grows from the head of the bat moth larvae and then protrudes from the ground. It looks like a plant. Grass" together constitute a complete "Cordyceps sinensis" [9].

On July 9, 2020, the International Union for Conservation of Nature listed it as "Vulnerable" in the Red List of Threatened Species [1]. The main factors threatening population decline are global climate change and overharvesting [11]. In 1999, it was listed as a national second-class protected species by China [8].

According to the results of modern pharmacological studies, Qinghai Cordyceps sinensis contains about 7% of cordycepin, 28.9% of carbohydrates, about 8.4% of fat, about 25% of protein, and 82.2% of fat is an unsaturated fatty acid. In addition, it also contains vitamin B12 and ergosterol, six-carbon sugar alcohols, alkaloids, etc. [8].

Cordyceps sinensis was officially included in the classics as a medicine, starting from the "Materia Medica Congxin" published in the Qing Dynasty, which pointed out that the effect of Cordyceps sinensis is "sweet and flat to protect the lungs, nourish the kidneys to stop bleeding, reduce phlegm, and relieve cough" [13]. Afterward, Cordyceps sinensis, together with ginseng and velvet antler, was called the three most valuable nourishing medicinal materials and enjoyed a great reputation[14].

Angelo collected high-quality Cordyceps sinensis from Qinghai Province, China, and used aseptic technique to isolate and purify various strains from the fruiting bodies of Cordyceps sinensis. The Institute of Microbiology, Chinese Academy of Sciences identified TCM777 as Paecilomyces bat moth. Preserve precious bacteria with liquid nitrogen.

Angelo's exclusive fermentation and production technology uses standard and automated procedures to carry out low-temperature fermentation, plate and frame pressing and freeze-drying to establish international standard quality control. With standardized procedures, raw materials, semi-finished products, and products are subjected to hygienic inspection, index component analysis, and biological activity testing. , and meet the national inspection standard specifications. TCM777 has obtained TQF certification and HALAL certification. The product quality and health and safety management align with this verification specification.

The antioxidant activity of Angelo’s exclusive Cordyceps TCM777 is three times higher than natural Cordyceps. It has been certified by the FDA. TCM-777 is a highly safe health food raw material and can promote health, increase physical strength, and regulate immune functions.

Angelo uses the characteristics of TCM777 to develop the high-tech biological dietary supplement Immune-Pro.The main ingredients Cordyceps sinensis mycelium TCM77+ superoxide dismutase (SOD) can improve immunity, reconcile qi and blood, and repair the immune system in the late stage of the epidemic*.

References:

1.Yang, Z.-L. Ophiocordyceps sinensis. The IUCN Red List of Threatened Species (IUCN). 2020, 2020: e.T58514773A58514845 [13 July 2020]. (Original content archived on 2020-12-12).

2.Ophiocordyceps sinensis (Berk.) G.H. Sung, J.M. Sung, Hywel-Jones & Spatafora 2007. MycoBank. International Mycological Association. [2011-07-19]. (Archived from the original on 2020-03-28).

3.Sung, G. H., et al. (2007). "A multi-gene phylogeny of Clavcipitaceae (Ascomycota, Fungi): identification of localized incongruence using a combinational bootstrap approach." Molecular Phylogenetics and Evolution 44(3): 1204-122 3.

4.Wang, Xiao-Liang; Yao, Yi-Jian. Host insect species of Ophiocordyceps sinensis: a review. ZooKeys. 2011-09-08, 127: 43–59. doi:10.3897/zookeys.127.802.

5.Li, Yi; Wang, Xiao-Liang; Jiao, Lei; Jiang, Yi; Li, Hui; Jiang, Si-Ping; Lhosumtseiring, Ngarong; Fu, Shen-Zhan; Dong, Cai-Hong; Yi-Jian. A survey of the geographic distribution of Ophiocordyceps sinensis. The Journal of Microbiology. 2011-12, 49 (6): 913–919. doi:10.1007/s12275-011-1193-z.

6.Chen Ruoyun, editor-in-chief. Chemistry of Edible and Medicinal Fungi in China. Shanghai: Shanghai Science and Technology Literature Publishing House. 2016.03: 89–90. ISBN 978-7-5439-6915-5.

7.Information Center. Notice of the General Administration of Food and Drug Administration on Stopping the Pilot Work of Cordyceps Sinensis in Health Food [2016] No. 21. Qinghai Provincial Food and Drug Administration. [2018-05-26]. (Original content archived in 2016- 11-06).

8.Editor-in-Chief Jiang Dacheng. Identification of Traditional Chinese Medicine. Beijing: China Agricultural University Press. 2016.01: 263. ISBN 978-7-5655-1163-9.

9.【Cordyceps sinensis】Basic introduction (page archive backup, stored in Internet Archives), Bai Restaurant

10.Organized by the Licensed Pharmacist Qualification Certification Center of the State Food and Drug Administration. Professional Knowledge of Traditional Chinese Medicine 1 2016. Beijing: China Medical Science and Technology Press. 2016.01: 383. ISBN 978-7-5067-8129-9.

11.Li, Yi; Tang, Zhiyao; Yan, Yujing; Wang, Ke; Cai, Lei; He, Jinsheng; Gu, Song; Yao, Yijian. Incorporating species distribution model into the red list assessment and conservation of macrofungi: A case study with Ophiocordyceps sinensis. Biodiversity Science. 2020-01-20, 28 (1): 99. doi:10.17520/biods.2019158.

12.Chinanews. Food and Drug Administration: Long-term consumption of Cordyceps sinensis has higher risks-China News. China News. [2018-05-26]. (Original content archived on 2020-12-12).

13.Edited by Liu Shaogui. Identification and application of commonly used Chinese herbal medicines. Changsha: Hunan Science and Technology Press. 2015.07: 515. ISBN 978-7-5357-8682-1.

14.Edited by Zhang Hongxing. Home Manual of Tonic Medicinal Materials. Wuhan: Hubei Science and Technology Press. 2015.01: 119. ISBN 978-7-5352-7060-3.